Symptoms and Diagnosis of Rheumatoid Arthritis

by Dr. Naseem Arshad

July 19, 2024

Rheumatoid arthritis is a disease of the joints that causes pain, swelling and stiffness — especially in the morning, lasting more than half an hour. Fingers and toes are often affected early and more severely, but many joints such as the wrists, knees, shoulders and ankles can also be involved.

Symptoms of rheumatoid arthritis

A key feature of rheumatoid arthritis is that joints on both sides of the body — right and left — are involved at the same time. Alongside joint pain, patients may also experience:

  • Prolonged morning stiffness (more than 30 minutes)
  • Fatigue and a general feeling of being unwell
  • Fever, muscle cramps and weight loss

Rheumatoid arthritis can begin in just one or two joints and then gradually spread, but sometimes it affects many joints severely from the very start. Beyond the joints, it can also affect the eyes, lungs, heart and skin, which is why it is considered a whole-body disease.

How rheumatoid arthritis is diagnosed

The patient's own description of their symptoms is often enough to point strongly towards the diagnosis. Specific blood tests are then used to support it:

  • Rheumatoid Factor (RF)
  • Anti-CCP antibodies

However, these tests need careful interpretation. It is possible to have a positive RF without having rheumatoid arthritis, which your rheumatologist will assess. It is also possible to have negative tests but still have the disease — this is known as seronegative rheumatoid arthritis.

Why timely treatment is crucial

According to guidelines, starting proper treatment within the first six months is important. This has two major benefits:

  1. It increases the chance of remission — complete control of the disease.
  2. It prevents joint damage and deformity over time.

If you have seronegative rheumatoid arthritis, it is just as important to follow your treatment plan closely.

Read more about what rheumatoid arthritis is and the treatment of rheumatoid arthritis, or see our full guide to rheumatoid arthritis treatment in Faisalabad.

Frequently asked questions

What are the main symptoms of rheumatoid arthritis?

The main symptoms are joint pain, swelling and stiffness — especially morning stiffness lasting more than half an hour. It usually affects both sides of the body, often starting in the fingers and toes, and can be accompanied by fatigue, fever and weight loss.

How is rheumatoid arthritis diagnosed?

Diagnosis is based mainly on the pattern of symptoms and a clinical examination, supported by blood tests such as Rheumatoid Factor (RF) and anti-CCP antibodies, and sometimes imaging. A rheumatologist interprets these together to confirm the diagnosis.

Can you have rheumatoid arthritis with negative blood tests?

Yes. Some patients have rheumatoid arthritis despite negative RF and anti-CCP tests — this is called seronegative rheumatoid arthritis. It is just as important to treat, so a rheumatologist's clinical assessment is essential.

How soon should rheumatoid arthritis be treated?

Guidelines recommend starting proper treatment within the first six months of symptoms. Early treatment increases the chance of remission and prevents long-term joint damage and deformity.

Dr. Naseem Arshad Rheumatologist Faisalabad

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